Do you know the knowledge of vaccination？

　　"I accidentally stepped on shit when I was walking, and I happened to have an injury on my foot. Do you want to get rabies vaccine?" You must want to know such a wonderful question. "After the baby is vaccinated, why do you have to wait for 30 minutes to leave the hospital?" You must be very concerned about such common problems. "With HPV vaccine, you can stay away from cervical cancer once and for all?" You must not miss such a hot question.

　　At the final of "Guangzhou Vaccination Science Popularization Competition in 2020" held recently, all kinds of knowledge about vaccines and vaccination made people learn a lot.

　　The birth process of vaccine is not simple.

　　Since ancient times, human beings have been fighting against viruses, and have gradually discovered the magic weapon to win — — Vaccine. There are several ways to produce vaccines, one of which is — — Take inactivated vaccine as an example to talk about the birth of vaccine.

　　First of all, scientists should isolate the virus from the source of infection. The isolated virus can not be used directly, and it needs to be processed before screening out the ideal strain. Then these strains are cultured and propagated on the cell matrix; These strains contain some impurities, which need to be removed by filtration. Then treated with formaldehyde and other solutions to make the strain lose its pathogenicity and retain its antigenicity; Finally, through a series of processing, inactivated vaccine can be born.

　　But this vaccine can’t be injected into human body at this time. In order to ensure safety and effectiveness, the vaccine needs to undergo strict tests at different levels. The first level is the animal test. After passing the animal test, it can be reported to National Medical Products Administration to apply for clinical trials. The clinical trial is divided into three phases. This is for the sake of safety, and the test population should increase in a step-by-step manner. Only after the safety of the first-phase clinical trial is ensured can the second-phase clinical trial be carried out to study its effectiveness. In the last three phases, a randomized, blind and placebo-controlled design should be adopted to comprehensively evaluate the effectiveness and safety of the vaccine in a wider range of people. All clinical trials generally take at least 3-8 years, and some even take more than 10 years. If the vaccine fails to meet the requirements in the test, it will be stopped or even terminated.

　　After passing the above-mentioned layer-by-layer tests, it is necessary to go through enterprise self-inspection, expert review, on-site inspection by the Food and Drug Administration, and identification by the Central Inspection Institute to confirm that the vaccine is safe and effective, the process is true, and the quality is controllable. At this time, the vaccine can be officially marketed and promoted.

　　Today’s children have been vaccinated to prevent various diseases shortly after birth. One of the most common phenomena is that babies are usually asked not to go home immediately after vaccination in the hospital, and can only go home after observation in the observation room for at least 30 minutes. Why is this? Is there anything unsafe about the vaccine? In fact, adverse reactions may occur after vaccination, but the probability of occurrence is very low. There are two kinds of adverse reactions, one is a relatively common general reaction, such as fever, redness and swelling at the injection site, poor appetite, etc. There is also an abnormal reaction, which means that the vaccine is qualified and the vaccination process is standardized, but it has brought some damage to the baby’s body. Both of these reactions belong to "adverse drug reactions with no fault on both sides".

　　If the baby’s body temperature does not exceed 38℃, you can use the method of physical cooling and pay attention to rest to return to normal; If the inoculation site is red, swollen and indurated, it is generally not necessary to deal with it, and special attention should be paid to it. It is forbidden to apply hot compress after inoculation with BCG. If the baby’s temperature exceeds 38℃ or the general reaction is serious, you should seek medical treatment immediately without delay.

　　Therefore, don’t go home immediately after vaccination, also for "just in case".

　　There is no need to get rabies vaccine when you step on shit when you have a foot injury.

　　When a Panyu player popularized the vaccination of rabies vaccine, he mentioned a new knowledge point that people didn’t know much about before: if a dog bites you, you can observe the dog for ten days. If the dog doesn’t get sick, then the remaining shots of rabies vaccine that we have started to vaccinate don’t need to continue.

　　We know that 95% of rabies in China is spread by sick dogs, followed by some carnivorous mammals, such as cats, bats, foxes, wolves and raccoons. Cold-blooded animals such as poultry, fish and insects will not infect and spread rabies. You don’t need rabies vaccine after being bitten by rodents, rabbits and rabbits. Infectious diseases of dogs, cats and other animals are usually spread to them by external animals. Once a cat or dog is bitten by an infectious animal, the incubation period of the virus in their bodies is generally more than one month, but only in the saliva of the cat or dog 3-5 days before the onset of the disease may rabies virus be carried. Therefore, for some cats and dogs that are confirmed to be healthy, such as domestic cats and dogs that have a clear history, are not free-range or wandering, have never been bitten by animals suspected of rabies, and have been regularly injected with rabies vaccine, it is not necessary to take rabies vaccine when bitten by these cats or dogs.

　　Someone asked, "I accidentally stepped on shit when I was walking, and I happened to have an injury on my foot. Do you want to get rabies vaccine?" In fact, there is no need to get rabies vaccine. But it is best to clean the wound in time to prevent infection by other germs.

　　However, most people are not sure whether the biting animal is healthy after being bitten by an animal, so it is certainly right to think of vaccination at the first time. However, the rabies vaccine needs 5 shots in the whole process, and there is an interval between every two shots, so it not only costs money, but also takes time. Here is a "ten-day observation method" worthy of attention — —

　　First of all, for peace of mind, you can get vaccinated first, and at the same time lock up the biting dog for observation; If the dog is still very healthy after ten days, which proves that the biting dog was not in the period of rabies infection at the time of the incident, then you don’t need to take the rest rabies vaccine. If the dog is abnormal during the observation period, then your vaccine must be finished.

　　Vaccination with HPV vaccine is not 100% away from cervical cancer.

　　Like "settled" in the female cervix of the HPV virus, the scientific name is human papillomavirus, which is the chief culprit leading to cervical cancer. According to the ICO (Catalan Cancer Institute) report on HPV and related diseases in China released in 2018, 98% of cervical cancer in China is caused by high-risk HPV infection. There is no specific medicine for HPV infection at present. However, human beings have developed an HPV vaccine. After vaccination, the body can produce antibodies to eliminate high-risk HPV, thus preventing cervical cancer.

　　It has been known that there are more than 200 family members of HPV virus, and only 14 species can really "make waves" on human cervix. These fourteen kinds are called high-risk HPV, among which HPV16 and 18 are the most powerful, and 69% of cervical cancer is attributed to them.

　　At present, the HPV vaccines on the market are bivalent, bivalent and bivalent. If you hit the price of 2 and 4, you can prevent about 70% of cervical cancer; The tetravalent vaccine can also prevent 6/11 types of 14 high-risk HPV, which can prevent sexually transmitted diseases caused by these two types of viruses; On the basis of 4 valence, 9 valence has the function of preventing 31/33/45/52/58 type, which can prevent 92% of cervical cancer. The ideal vaccination time of HPV vaccine is before sex, that is, before the first exposure to HPV infection, but women who have had sex can also benefit from HPV vaccination.

　　Why does HPV appear in the human body? Mainly through sexual behavior, or contact with unclean sanitary ware or supplies. It is worth noting that women who are sexually active and have many sexual partners are particularly vulnerable to infection. But not being infected with high-risk HPV means getting cervical cancer. Only when high-risk HPV is continuously infected for 10 to 20 years will it naturally evolve into cancer. In this process, most people’s body functions can remove HPV.

　　It is worth reminding that the HPV vaccine is not once and for all. The HPV virus family is "numerous", and about 7% of cervical cancer can not be prevented by vaccination with HPV vaccine for the time being. So if you are old enough to have regular screening for cervical cancer, you should remember to have regular screening. If HPV vaccination is the primary prevention of cervical cancer, regular cervical cancer screening is the secondary prevention. Only when primary and secondary prevention are done, the "big devil" of cervical cancer will not be easily encountered. (Yangcheng Evening News reporter Li Gang)